Cerebellar atrophy in an epileptic child: is it due to phenytoin?

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2000-10-04
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Abstract
A four and half year old epileptic child on phenytoin therapy since one year presented with signs of cerebellar dysfunction. Serum phenytoin level was high (33 mcg/ml) and computerised tomographic scan of the brain showed severe generalised cerebellar atrophy. The cerebellar signs represented drug over dosage and toxicity and persisted long after omission of phenytoin.
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Ahuja SR, Karande S, Kulkarni MV. Cerebellar atrophy in an epileptic child: is it due to phenytoin? Journal of Postgraduate Medicine. 2000 Oct-Dec; 46(4): 278-9
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https://imsear.searo.who.int/handle/123456789/115988
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Journal of Postgraduate Medicine