Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine.
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2008-10-28
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Abstract
Lamotrigine is a commonly used agent for seizure control in epilepsy. There are limited data on the adverse effects of lamotrigine in overdose. We report a number of serious side-effects associated with a large overdose of lamotrigine. A 23-year-old female presented to the emergency department after taking an intentional overdose of 9.2 g of lamotrigine, 56 mg of chlorpheniramine, and 220 mg of citalopram. On admission, she had a reduced level of consciousness and electrocardiographic abnormalities; a widened QRS and a prolonged corrected QT (QTc) interval. Prompt treatment with early intubation, along with the use of magnesium for cardioprotection and administration of sodium bicarbonate may have aided in a quick recovery with a short intensive care stay and good outcome.
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Venkatraman N, O'Neil D, Hall AP. Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine. Journal of Postgraduate Medicine. 2008 Oct-Dec; 54(4): 316-7