Leucocyte adhesion defect-1.
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2008-06-05
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Leucocyte adhesion defect (LAD) is an inherited disorder of phagocytic function. It is characterized by inability of the leucocytes, in particular neutrophilis to migrate from the blood stream towards sites of inflammation. LAD -1 is characterized by the absence of b 2 integrins (CD 11 / CD18) on leucocytes. This disorder is characterized by delayed separation of the umbilical cord, recurrent severe infections, periodontitis, and delayed wound healing. We report an infant where the diagnosis was confirmed by flow cytometry.
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Jothilakshmi K, Priya S, Matthai J. Leucocyte adhesion defect-1. Indian Pediatrics. 2008 Jun; 45(6): 507-9