Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors.

No Thumbnail Available
Date
1991-10-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Combination chemotherapy studies were carried out in vivo against sarcoma 180 (ascites)(S180) and Ehrlich (ascites) carcinoma (EAC) tumours using cytotoxic drugs and methoxyphenyl maleamic acid (MPMA), an intermediate in the synthesis of pyrrolidine-nitrogen-mustards. Preliminary data have suggested that the combination of 5-fluorouracil (5-FU) and methoxyphenyl maleamic acid (MPMA) was more active than 5-FU used singly against EAC tumour. The possible therapeutic potential of this combination was further investigated in EAC tumour.
Description
Keywords
Citation
Indap MA, Ambaye RY. Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors. Journal of Postgraduate Medicine. 1991 Oct; 37(4): 211-5
URI
https://imsear.searo.who.int/handle/123456789/115144
Collections
Journal of Postgraduate Medicine