Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system.
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2008-12-17
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Abstract
A functional mouse CLOCK protein has long been thought to be essential for mammalian circadian clockwork function, based mainly on studies of mice bearing a dominant negative, antimorphic mutation in the Clock gene. However, new discoveries using recently developed Clock-null mutant mice have shaken up this view. In this review, I discuss how this recent work impacts and alters the previous view of the role of CLOCK in the mouse circadian clockwork.
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53 references.
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Debruyne JP. Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system. Journal of Genetics. 2008 Dec; 87(5): 437-46