Cybil induced hepatobiochemical changes in wistar rats.
No Thumbnail Available
Date
2005-10-08
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Cybil, 25%EC formulation of Cypermethrin, induces biochemical changes in the liver of wistar rats after oral intubation of the same at acute (one day) and subacute (7, 14 and 21 days) levels. The changes were tallied with the controls run simultaneously. LD50 of Cybil was estimated to be 622mg/kg body weight The acute dose is 80mg/kg body weight exposed for one day i.e. 24 hours and subacute dose is 4mg/kg body weight exposed for 7, 14 and 21 days. When compared with the control values, both the doses enhanced the level of glycogen, cholesterol, total lipid and acid phosphatase activities, while decreased activity of alkaline phosphatase. Alterations in glycogen, cholesterol, total lipid, acid phosphatase and alkaline phosphatase resulted in the impairement in liver physiology.
Description
Keywords
Citation
Singh VK, Dixit P, Saxena PN. Cybil induced hepatobiochemical changes in wistar rats. Journal of Environmental Biology. 2005 Oct; 26(4): 725-7