Molecular mechanism of insulin resistance.
No Thumbnail Available
Date
2007-03-17
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity,thereby causing insulin resistance and type 2 diabetes.However,the underlying mechanism involved is still unclear.In searching for the cause of the mechanism,it has been found that palmitate inhibits insulin receptor (IR)gene expression,leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKC(eta) causes this reduction in insulin receptor gene expression.One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies.We provide an overview of this important area,emphasizing the current status.
Description
63 references.
Keywords
Citation
Bhattacharya S, Dey D, Roy SS. Molecular mechanism of insulin resistance. Journal of Biosciences. 2007 Mar; 32(2): 405-13