Uterotropic effect of clofibrate and phenylbutazone in immature female rats.
No Thumbnail Available
Date
1982-04-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The uterotropic effect of clofibrate and phenylbutazone was studied in immature female rats. A significant increase in the uterine wet weight was observed following clofibrate and phenylbutazone administration. Clofibrate but not phenylbutazone synergized with the uterotropic effect of ethinyl-oestradiol. Phenylbutazone pretreatment significantly decreased the pentobarbitone sleeping time. The uterotropic effect of clofibrate and phenylbutazone might involve displacement of 17-beta oestradiol (or ethinyl oestradiol) from plasma albumin binding sites in rats.
Description
Keywords
Citation
Chandra D, Thulasimany M, Biswas AR. Uterotropic effect of clofibrate and phenylbutazone in immature female rats. Indian Journal of Physiology and Pharmacology. 1982 Apr-Jun; 26(2): 147-51