Central modulation of Brewer's yeast-induced peripheral inflammation by neuropeptides bradykinin and substance P.

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Date
1996-10-01
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Abstract
Possible modulation of the Brewer's yeast-induced peripheral inflammation by two central neuropeptides, bradykinin and substance P (SP), was investigated in rats. Centrally administered bradykinin significantly increased pedal oedema and pain threshold whereas, SP produced significant augmentation of oedema volume and nociception. The results of the present study indicate that central bradykinin exerts pro-inflammatory and analgesic effects whereas, central SP exerts pro-inflammatory and pro-nociceptive effects on Brewer's yeast-induced peripheral inflammation.
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Hore SK, Tripathi HC, Tandan SK, Kumar D. Central modulation of Brewer's yeast-induced peripheral inflammation by neuropeptides bradykinin and substance P. Indian Journal of Physiology and Pharmacology. 1996 Oct; 40(4): 367-71
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https://imsear.searo.who.int/handle/123456789/108697
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Indian Journal of Physiology and Pharmacology