General pharmacology of Vitex leucoxylon Linn leaves.

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Date
1994-04-01
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Abstract
Ethanol extract (ETE) and cold aqueous infusion (CAI) of Vitex leucoxylon leaf were evaluated in a battery of tests to define the activity profile of the plant. CAI depressed SMA, antagonised d-amphetamine stereotypy and oxotremorine tremors, shortened the duration of mice immobility in behavioural 'despair' test and lowered serum total cholesterol level. ETE showed significant inhibition of carrageenin paw oedema and granulation tissue formation in rats. Suppression of acetic acid writhing was observed with both ETE and CAI. LD50 value of ETE was > 3000 mg kg-1 (ip) and that of CAI 1050 (800-1200) mgkg-1.
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Makwana HG, Ravishankar B, Shukla VJ, Nair RB, Vijayan NP, Sasikala CK, Saraswathy VN, Bhatt SV. General pharmacology of Vitex leucoxylon Linn leaves. Indian Journal of Physiology and Pharmacology. 1994 Apr; 38(2): 95-100
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https://imsear.searo.who.int/handle/123456789/108650
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Indian Journal of Physiology and Pharmacology