Morphine-induced modulation of sciatic nerve stimulation evoked blood pressure responses.
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1991-04-01
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Abstract
Effect of i.v. morphine (1-2 mg/kg) on blood pressure changes evoked by sciatic nerve stimulation (SNS) were studied in chloralose anaesthetised cats. SNS gave a depressor, pressor or a biphasic BP response generally linked to the parameters of stimulation. Morphine produced marked attenuation of depressor and some facilitation of pressor response, suggesting a possible reciprocal relationship between depressor and pressor responses. Depressor response has been correlated with deep tissue or visceral pain mediated through A delta fibres and pressor response to cutaneous nociception involving C fibres or non nociceptive input via group II fibres. Involvement of medullary regions in differential modulation of these depressor and pressor response has been suggested.
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Bhattacharya N, Mahajan S, Sharma KN. Morphine-induced modulation of sciatic nerve stimulation evoked blood pressure responses. Indian Journal of Physiology and Pharmacology. 1991 Apr; 35(2): 125-9