Antagonism of anthracene-9-carboxylic acid as screening test for muscle relaxants.
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1976-10-01
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Abstract
Veratrinic response produced by anthracene-9-carboxylic acid in mice has been used as a model for studying effect of variety of drugs which induce muscle relaxation. None of the drugs listed as general depressants, central muscle relaxants, neuromuscular blocking agents and anti-convulsants were effective even at doses causing 100% loss of righting reflex. Local anaesthetics/direct acting muscle relaxants were effective. This simple model employed in conjunction with Straub's tail test can differentiate various categories of muscle relaxants and their mechanism of action.
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Sethi PD. Antagonism of anthracene-9-carboxylic acid as screening test for muscle relaxants. Indian Journal of Physiology and Pharmacology. 1976 Oct-Dec; 20(4): 239-41