Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue.
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2005-01-11
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Abstract
Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (P<0.001) in the wistar rat. The degree of decrease of these enzymes was significantly less (P<0.001) when rats were treated with curcumin, a natural constituent Curcuma longa. Curcumin seems to prevent oxidative damage mediated through selenium and protect the dehydrogenases possibly through its anti-oxidative property.
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Padmaja S, Raju TN. Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue. Indian Journal of Physiology and Pharmacology. 2005 Jan; 49(1): 111-4