Administration of the plasticizer di (2-ethylhexyl) phthalate alters glycoconjugate profile.
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1995-07-01
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This study was undertaken to evaluate the level of glycoproteins and sialic acid in rats fed di (2-ethylhexyl)-phthalate (DEHP) in the diet for 24 weeks. Protein-bound hexose, hexosamine and sialic acid were increased in plasma and liver of rats treated with DEHP, whereas the erythrocyte membrane showed a reduction following DEHP administration. Evaluation of glycoproteins is a useful indicator of the carcinogenic process. It is suggested that profound alterations in membrane components observed in the present study may be related to the carcinogenic potential of DEHP.
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Selvam S, Nagini S. Administration of the plasticizer di (2-ethylhexyl) phthalate alters glycoconjugate profile. Indian Journal of Physiology and Pharmacology. 1995 Jul; 39(3): 252-4