Modification of the toxicity of acetylcholine by prior atropinization in mice.

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1978-01-01
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Abstract
The potentiation of acetylcholine (Ach) toxicity in mice with prior atropinization was tested. The experiments were carried out with three doses of 200 mg, 300 mg, and 400 mg/kg of Ach administered ip. Prior atropinization was observed to potentiate the Ach toxicity at all dose levels of atropine except the highest in the group that received Ach 200 mg/kg and the results were variable in the other two groups.
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Sanan S, Goel NK. Modification of the toxicity of acetylcholine by prior atropinization in mice. Indian Journal of Physiology and Pharmacology. 1978 Jan-Mar; 22(1): 98-100