Organ fluid compartments in rats exposed to high altitude.
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1980-07-01
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Rats were exposed to acute hypobaric hypoxia corresponding to an altitude of 6,100 m for 5 hours and 24 hours and were studied for organ fluid changes. Total water and extracellular water content of various organs, i.e. lung, liver, spleen, heart, kidney, muscle, brain testis and subcutaneous tissue were determined by the difference of dry and wet weights and using radiobromide-82 respectively. Lung and liver were found to be significantly hydrated with lower water contents in subcutaneous tissue, spleen and muscle on prolonged exposure. The data indicated a shift of fluids from extracellular to intracellular compartment.
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Jain SC, Rawal SB, Divekar HM, Nayar HS. Organ fluid compartments in rats exposed to high altitude. Indian Journal of Physiology and Pharmacology. 1980 Jul-Sep; 24(3): 177-82