The effect of acute and chronic treatment of verapamil on pressor response to angiotensin II in rats.
No Thumbnail Available
Date
1986-04-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The effect of verapamil on pressor response to Angiotensin II (A II) was investigated in rats. The responses to A II (10, 20, 40 ng, iv) was reduced after verapamil (50 and 100 micrograms, iv per rat) in a dose dependent manner. Treatment for 5 day with verapamil (18 mg/100 g/day, po) let to some reduction in basal blood pressure but pressor response to A II was not changed. Treatment for 20 days significantly reduced the basal blood pressure and increased the responsiveness to A II. it is concluded that Ca++ plays a major role in the pressor responses to A II and that chronic treatment with verapamil may reduce basal blood pressure.
Description
Keywords
Citation
Lall SB, Kheterpal K, Rajdev S, Gupta YK. The effect of acute and chronic treatment of verapamil on pressor response to angiotensin II in rats. Indian Journal of Physiology and Pharmacology. 1986 Apr-Jun; 30(2): 145-8