Haematological and erythrocyte membrane changes induced by amiodarone, in rats.
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1992-10-01
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Abstract
The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.
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Padmavathy B, Devraj NS, Devraj H. Haematological and erythrocyte membrane changes induced by amiodarone, in rats. Indian Journal of Physiology and Pharmacology. 1992 Oct; 36(4): 276-8