Effect of third ventricular injection of beta-endorphin on the electrophysiological responses of some regions of endocrine hypothalamus.
No Thumbnail Available
Date
1985-04-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Multiunit activity (MUA) of arcuate nucleus and cortical EEG were recorded in the regularly cycling female rats on the day of proestrous under urethane anaesthesia. The MUA was compared before and after injection of beta-endorphin in third ventricle. In some animals MUA increased after 30-40 min and persisted for 3-4 hr, in others MUA got inhibited within 5-10 min of injection of beta-Endorphin and effect lasted for 5-6 hr. There was no change in frontoparietal EEG activity. In another group of animals medial pre-optic responses (MPO) to stimulation of medial amygdala were tested before and after ventricular infusion of beta-endorphin. Most of the facilitatory MPO responses got blocked. These observations suggest the involvement of opioid receptors in the mediation of neuroendocrine control of preovulatory events through the amygdalo-preoptico-medial basal hypothalamic axis. There seems to be heterogeneity of beta-endorphin receptors in the arcuate nucleus.
Description
Keywords
Citation
Tandon OP, Sharma KN. Effect of third ventricular injection of beta-endorphin on the electrophysiological responses of some regions of endocrine hypothalamus. Indian Journal of Physiology and Pharmacology. 1985 Apr-Jun; 29(2): 75-82