Acute neurobehavioural toxicity of phosphamindon and its drug-induced alteration.

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Date
1990-04-01
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Abstract
Phosphamidon, a systemic organophosphate insecticide, (1.4 mg/kg - dose 1/4th of LD50 given ip), produced several autonomic, neurological and behavioral effects in mice with peak effects being at 15 min. Similar dose in rats also abolished conditioned avoidance response. Pre-treatment with atropine, iproniazid, alpha-methyl-p-tyrosine, p-chlorophenylalanine or thiosemicarbazide reduce many of these effects. This suggests that phosphamidon toxicity involves the central cholinergic, adrenergic, serotonergic and GABAergic systems in addition to peripheral cholinergic effects.
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Agarwal AK, Sankaranarayanan A, Sharma PL. Acute neurobehavioural toxicity of phosphamindon and its drug-induced alteration. Indian Journal of Physiology and Pharmacology. 1990 Apr; 34(2): 101-4
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https://imsear.searo.who.int/handle/123456789/106551
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Indian Journal of Physiology and Pharmacology