Effect of dothiepin on nociceptive response in diabetic rats.
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1992-04-01
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Abstract
In alloxan-diabetic rats of 4 wk duration with blood glucose levels of about 300 mg/100 ml, the tail flick reaction time (TFRT) to thermal stimuli was significantly elevated (P less than 0.25), indicating hypoalgesia. Intraperitoneal dothiepin, injections of 25 mg & 50 mg/kg body weight per day did not significantly alter the TFRT, either in control or in diabetic rats, following either acute (one dose), or short term (once a day for five days) administration. It is concluded that at least in the dosage schedule used herein, dothiepin does not influence hypoalgesia of diabetic neuropathy.
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Rani MA, Andrade C, David J. Effect of dothiepin on nociceptive response in diabetic rats. Indian Journal of Physiology and Pharmacology. 1992 Apr; 36(2): 93-6