Effect of chronic treatment with atenolol and prazosin in streptozotocin induced diabetic rats.
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1996-07-01
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Diabetes-mellitus was induced in rats by single intravenous injection of (45 mg/kg) streptozotocin (STZ). STZ diabetic rats showed hypertension, decreased cardiac functions, cardiomyopathy and hypercholesterolemia observed at the end of six weeks. Chronic treatment with atenolol (10 mg/kg) for six weeks in the diabetic rats reduced the elevated blood pressure, but failed to prevent STZ induced other complications. Chronic treatment with prazosin (1 mg/kg, po) in the diabetic rats, reduced the elevated blood pressure and also partially prevented hypercholesterolemia, cardiac dysfunctions and in particular the cardiomyopathy. The results suggest that prazosin may be a better option as compared to atenolol in hypertension when it is associated with diabetes mellitus.
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Goyal RK, Bangaru RA, Lakkad NB, Rao MV. Effect of chronic treatment with atenolol and prazosin in streptozotocin induced diabetic rats. Indian Journal of Physiology and Pharmacology. 1996 Jul; 40(3): 220-4