Effect of centrally administered angiotensin on urine output in dogs.

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1982-01-01
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The effect of angiotensin II was studied on urine volume, urine sodium and potassium sodium and potassium in mongrel dogs. Intracerebro-ventricular (icv) administration of angiotensin (100.0 micrograms) caused significant increase in urine volume without significant change in urine sodium and potassium level. Similar effect is also obtained in denervated dogs. The effect of intracerebroventricularly administered angiotensin is possibly due to the decrease in secretion of the Antidiuretic hormone (ADH) from posterior lobe of pituitary gland.
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Singh KN, Saxena VC, Mishra V, Singh M. Effect of centrally administered angiotensin on urine output in dogs. Indian Journal of Physiology and Pharmacology. 1982 Jan-Mar; 26(1): 69-72