HLA-DQB1*05 association with Hashimoto's thyroiditis in children of Northern Greek origin.

Giza, Styliani; Galli-Tsinopoulou, Assimina; Lazidou, Panagiota; Trachana, Maria; Goulis, Dimitrios

HLA-DQB1*05 association with Hashimoto's thyroiditis in children of Northern Greek origin.

Date

2008-06-05

Authors

Giza, Styliani

Galli-Tsinopoulou, Assimina

Lazidou, Panagiota

Trachana, Maria

Goulis, Dimitrios

Abstract

In order to investigate HLA-DRB1 and HLADQB1 gene polymorphisms in Northern Greek pediatric population with Hashimoto's thyroiditis (HT), we analyzed the distribution of these alleles in 17 patients and in 181 healthy subjects using polymerase chain reaction. No significant association was detected between HT and alleles analyzed. However, HLA-DQB1*05 was significantly increased in patients with age of diagnosis > 10 years (87.5%) compared to those with age of diagnosis <or= 10 years (33.3%) (P=0.05). These results question the role of sexual maturity in combination with HLA-DQB1*05 as predisposing factor for the onset of HT in Northern Greek children and adolescents.

Citation

Giza S, Galli-Tsinopoulou A, Lazidou P, Trachana M, Goulis D. HLA-DQB1*05 association with Hashimoto's thyroiditis in children of Northern Greek origin. Indian Pediatrics. 2008 Jun; 45(6): 493-6