Browsing by Author "Singh, P"
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Item Acute viral hepatitis with agranulocytosis.(1982-05-01) Singh, M P; Singh, P; Ranjan, S; Singh, A NItem Ammonia assimilation by Mycobacterium smegmatis during growth on different nitrogenous sources.(1978-04-01) Singh, P; Venkitasubramanian, T AItem Antihistamine-induced reduction of eosinophilic and antibody response to Salmonella typhi O vaccine in guinea pigs.(1972-01-01) Chatterjee, S C; Singh, PItem Association of vitamin A, vitamin C and zinc with laryngeal cancer.(2003-04-13) Kapil, U; Singh, P; Bahadur, S; Shukla, N K; Dwivedi, S; Pathak, P; Singh, RBACKGROUND: The incidence of the cancers of the oral cavity, pharynx, esophagus and larynx in different population groups of India is amongst the highest reported in Asian countries. There is evidence that high dietary carotenoids and vitamin C may possibly decrease the risk of laryngeal cancer. Limited data is available from India on the association between these micronutrients and the risk of laryngeal cancer. AIMS: To assess the levels of vitamin A, vitamin C and zinc in laryngeal cancer patients and healthy controls. SETTING AND DESIGN: A hospital based case- control study. MATERIAL AND METHODS: One hundred and fifty five laryngeal cancer patients and a control group of 155 healthy individuals constituted the study population. Individuals in the control group were individually matched with the patients for their age +/- 2 years, sex and place of residence. Venous blood was drawn from the cases and controls and estimations of vitamin A, zinc and vitamin C was done utilizing the standard procedures. STATISTICAL ANALYSIS USED: Paired 't' test to compare the mean serum levels of vitamin A and zinc and plasma vitamin C between laryngeal cancer patients and controls. Univariate logistic regression analysis to calculate the odds ratios and the confidence intervals. RESULTS: The mean serum vitamin A, zinc and plasma vitamin C levels were significantly lower in laryngeal cancer patients as compared to the controls. CONCLUSIONS: The findings of the present study indicated a strong association of these micronutrients with laryngeal cancer in the Indian population.Item Atypical presentations of Sheehan's syndrome.(2006-09-11) Krishna, Kavita; Singh, P; Pradhan, A BItem Bacteraemia in urological surgical procedures.(1994-10-01) Goyal, S C; Singh, P; Khurana, S; Ram, SItem Bacteriological study of cases of upper and lower urinary tract infection.(1974-12-01) Singh, P; Taneja, O P; Bhatia, V N; Agarwal, D SItem Bilateral conjunctivitis associated with Nocardia asteroides (a case report).(1982-05-01) Gupta, M L; Singh, P; Goyal, B K; Goyal, A; Sharma, R DItem Bilateral spontaneous pneumothoraces in osteogenic sarcoma and extragonadal germ cell tumour.(1994-01-01) Arora, R; Singh, P; Aggarwal, R K; Virdi, H K; Singh, K K; Kang, H SBilateral spontaneous pneumothoraces are uncommon complications of metastatic pulmonary disease especially antedating frank metastases or developing as a complication of chemotherapy. It is seen more often in osteogenic sarcoma and uncommon in extra gonadal germ cell tumour. It may correct spontaneously or need tube drainage.Item Calcification of the thoracic ligamentum flavum: a rare cause of myelopathy.(2001-08-12) Singh, P; Kar, A M; Garg, R KCompressive myelopathy secondary to ossification or calcification of the ligamentum flavum is a rare entity. Clinical features and magnetic resonance imaging findings of a patient of dorsal cord compression who improved remarkably with surgery are reported.Item Chemotherapy-radiotherapy combination in the treatment of carcinoma of the cervix.(1985-12-01) Singh, P; Dharmalingam, S K; Tan, M K; Tan, C KThree hundred eligible patients with carcinoma of the cervix out of a total of 560, registered between July 1981 and June 1983 were randomized into receiving either radiotherapy alone or radiotherapy plus weekly injection of bleomycin 15 mg and mitomycin C4 mg. To date (22 Feb. 1985) patients have been evaluated for response to therapy at 3 months and 1 year from completion of treatment. Although both at 3 months and 1 year the combined modality treatment appears to be marginally better (68% and 71% at 3 months, 56% and 63% at 1 year), the long term results remain uncertain at present. Treatment by the addition of chemotherapy to radiation was however well tolerated with a few complications.Item Chronic hepatitis--changing trends.(1998-05-29) Sood, A; Singh, P; Midha, VThe clinical expressions, courses and consequences of hepatitis caused by different viruses (A,B,C,D,E,G) are different. Diagnosis of hepatitis is incomplete unless its etiology is specified and for chronic hepatitis, the etiology is apparent in almost all cases when autoimmune and metabolic diseases are also included. Hence, the classification based only on histology is not adequate and emphasis should also be on the etiology. The prognostic indices governing a response to interferon therapy in patients with chronic viral hepatitis have advanced with the knowledge of role played by viral genotypes, serum ferritin, hepatic iron concentration, viral quantification, and severity of histology. There have been recent changes in the definition and classification of autoimmune hepatitis as well as there is availability of newer immunosuppressive agents with encouraging results.Item Chylothorax: A rare presentation of Constrictive Pericarditis.(2005-10) Singh, P; Shah, K V; Shah, N T; Chauhan, J B; Shah, B; Jindal, S; Gami, SA 22-year male patient presented as bilateral chylous pleural effusion. There was no evidence of intra-abdominal or pulmonary pathology. Further investigation proved constrictive pericarditis as the most likely etiology. Patient underwent pericardiectomy by a cardio thoracic surgeon. The diagnosis was of tuberculous pericarditis. Patient responded to antitubercular treatment. Constrictive pericarditis as a cause of chylothorax is rare but should be considered in the differential diagnosis of chylothorax.Item Citizen charter versus medical ethics and health legislation.(1998-09-04) Singh, P; Chandra, HItem Clinico-etiological Characteristics of Cystic Lung Disease: A Retrospective Study(Jaypee Brothers Medical Publishers Pvt. Ltd, 2023-03) Singh, P; Vasan, AS; Ahuja, NB; Bhattacharjee, S; Madakshira, MG; Hegde, A.Introduction: Diffuse cystic lung diseases (CLDs) are a heterogeneous group of uncommon disorders with characteristic imaging appearance. Cystic lung disease is a significant cause of mortality and morbidity with a wide spectrum of radiological presentations and etiological differentials. Though the literature is widely available on radiological approaches to CLD, a knowledge gap exists on the etiological spectrum, especially in the Indian scenario, as it is an orphan group of lung disorders. The interest and experience among pulmonologists regarding CLD are growing with the widespread use of CT scans. Clinical, radiographic, and histological findings are often essential for proper diagnosis, and multidisciplinary approach is required for optimal management of such cases. In our study, through real-world cases, we have highlighted the clinical manifestations and diverse etiological spectrum of CLD. Since these disorders are rare, incurable, and have variable disease progression, the authors have tried to address the holistic approach of this relatively less-understood group of disorders. Aims and objectives: The aim of the study was to identify clinical characteristics and etiological spectrum of patients manifesting with diffuse cystic lung disease radiologically. Materials and methods: In this retrospective analysis, the hospital electronic database was screened with Boolean operations and keywords for cysts OR pneumothorax. Among a total of 4,479 patients admitted to the respiratory ward /ICU during the period of January 2020–September 2022 at a tertiary care center in northern India, 14 patients with radiological diagnosis of CLD matched the relevant search. All relevant data of these patients were retrieved from the records. Results: Our patients presented predominantly with symptoms of cough and breathlessness. About 4 patients had pneumothorax as the first presentation. The mean age of presentation was 42.14 (standard deviation 12.6, age range 16–62 years). About 64% (n = 9/15) patients were females. The various etiologies identified were lymphangioleiomyomatosis (LAM), lymphocytic interstitial pneumonia, Birt–Hogg–Dube syndrome, hypersensitivity pneumonitis, Pneumocystis jirovecii pneumonia, and cystic metastasis, and in one patient, no definite cause was found despite detailed evaluation. Conclusion: Cystic lung disorders are a less commonly diagnosed entity with rare etiologies. In our study, we found a female preponderance and LAM as the commonest CLD. Pneumothorax is a sentinel event and commonly the presenting complaint in CLD. Identification of the etiology can help in institution of definite therapy when available. In view of unpredictable disease progression and outcome, these diseases warrant follow-up and imaging surveillance.Item Cognitive functions in patients of primary affective disorder on prophylactic lithium treatment.(1988-09-01) Sharma, I; Singh, PItem A comprehensive examination of Smad4, Smad6 and Smad7 mRNA expression in pancreatic ductal adenocarcinoma.(2011-04) Singh, P; Wig, J D; Srinivasan, R; Radotra, B DBackground: Smad4, Smad6 and Smad7 are important molecules in TGF-beta pathway, which plays an important role in pancreatic ductal adenocarcinoma (PDAC) biology. Aims : This study examined the expression profiles of Smad4, Smad6 and Smad7 mRNA in patient samples of PDAC and their relationship to Smad protein expression, SMAD4 gene mutations, clinicopathological parameters and patient survival. Settings and Design: Surgically resected, paired normal and tumor tissues of 25 patients of PDAC were studied. Materials and Methods: Protein and mRNA levels were assessed by immunohistochemistry and RT-PCR, respectively. Statistical Methods: Statistical analysis was done using Student's t-test, Pearson's chi-square test, Spearman's Rank Correlation, Pearson's Correlation test and Kaplan-Meier Logrank test. Results: While there was a highly significant difference in the protein levels of all three Smads in tumor as compared to normal samples, mRNA levels were significantly different only for Smad4. Protein levels did not correlate significantly with mRNA levels for any of the three Smads. The mRNA levels of Smad4 and Smad6, Smad4 and Smad7, and Smad6 and Smad7 in tumor samples showed a significant positive correlation. The relationship of Smad4 mRNA expression to SMAD4 gene status and Smad4 protein expression was discordant and there was no significant correlation between mRNA expression and clinicopathological parameters and patient survival. Conclusion : The absence of concordance between SMAD4 gene status, mRNA expression and Smad4 protein expression suggests the presence of other regulatory mechanisms in Smad4 transcription and translation in PDAC.Item Contact vitiligo: etiology and treatment.(2003-01-24) Singh, P; Singh, J; Agarwal, U S; Bhargava, R KFifty patients of contact vitiligo were studied. Etiological agents of contact vitiligo were identified by clinical history, distribution of lesions and patch testing with suspected material. All patients were advised to avoid the suspected agent and treated with PUVASOL and topical steroid. Out of 50 patients (Male 8%, Female 92% age 14-60 years)., etiological agent of contact vitiligo was found to be sticking bindi alone in 24 (48%), while bindi along with other etiological agents were found to be purse, foot wear, plastic watch strap, lipstick and tooth paste in 14 (28%) cases. 14 (28%) patients also had disseminated lesions of vitiligo along with contact vitiligo. Positive reaction with patch testing was observed in 18 (36%) while depigmentation was seen in 4 (8%) cases. We observed that response of treatment was better in patients with shorter duration of disease while poor response was seen in patients with longer duration of disease.Item Cord blood cholesterol in term and preterm newborns.(1994-10-01) Singh, J; Purohit, M; Singh, P; Thappa, D MItem Correlation between the preoperative serum prostate specific antigen, Gleason score, and clinical staging with pathological outcome following robot-assisted radical prostatectomy: An Indian experience.(2011-10) Singh, P; Dogra, P N; Gupta, N P; Nayyar, R; Seth, A; Javali, T D; Kumar, RObjectives: To correlate the preoperative serum prostate specific antigen (PSA), Gleason score, and clinical staging with pathological outcome following robot-assisted radical prostatectomy (RARP) in Indian men with clinically localized cancer prostate. Materials and Methods: A prospective study analysis was done for 166 consecutive patients of prostate cancer who underwent RARP at our center from June 2006 to October 2009. Preoperative workup included serum PSA, biopsy Gleason score, and clinical staging. The preoperative parameters were correlated with final Gleason score, capsular penetration, seminal vesicle involvement, and lymph node status on final histopathology. Results: The mean age was 64 years (range: 50-76 years) with mean and median PSA of 17.98 ng/ml (range: 0.3-68.3 ng/ml) and 12.1 ng/ml, respectively. With increase in preoperative Gleason score, chance of organ confinement decreases (P=0.002) and capsular penetration increases (P=0.004) linearly. With increasing serum PSA, there is linear decrease in trend of organ-confined disease (P=0.03) and increased chances of seminal vesicle involvement (P=0.02). Patients with higher clinical stage have less probability of localized disease (P=0.007) and more chances of capsular penetration (P=0.04) and seminal vesicle involvement (P=0.004). Conclusion: Our data suggest that patients with higher preoperative serum PSA, Gleason score, and clinical stage have more chances of advanced pathological stage following RARP.