Browsing by Author "Mukherjee, S K"
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Item Abdominal injuries.(1969-05-16) Mukherjee, S KItem Absence of pulmonary artery. A case report with review of literature.(1966-01-01) Banerjea, J C; Bose, P; Mukherjee, S KItem Acid phosphatase activity as an index of pancreatic beta-cell function.(1981-03-01) Chatterjee, A K; Mukherjee, S KItem Activation of probable proinsulin-converting enzymes in pancreatic islets: its correlationship with rate of insulin biosynthesis.(1984-08-01) Chatterjee, A K; Mukherjee, S KItem Acute obstructive suppurative cholangitis. A review of 26 classes.(1973-04-01) Mukherjee, S KItem Anti-secretagogue effect of lithium on isolated rat islets of Langerhans.(1989-02-01) Chandrasekar, B; Mathur, S K; Mukherjee, S KAdministration of lithium carbonate solution (50 mg/kg, po, twice daily) to Charles Foster male albino rats for 45 consecutive days caused an intolerance to oral glucose. Inhibition in (pro)insulin biosynthesis followed by a significant fall in immunoreactive insulin release was seen in islets isolated from identically treated rats. As the activities of acid phosphatase and cathepsin B were unaltered, it is possible that the anti-secretagogue effect is sequential to inhibition of (pro)insulin biosynthesis by lithium.Item The behaviour of blood pressure in patients with acute renal failure.(1970-07-01) Mukherjee, S KItem Biochemical activities of denatured covalently closed circular duplex DNA.(1993-04-01) Santra, C R; Mukherjee, S K; Thakur, A RCovalently closed circular duplex DNA when exposed to high alkaline pH followed by neutralization yields a collapsed state structure (form I(d)) that can undergo transition to form I and was susceptible to S1 nuclease. Form I(d), in spite of its compact structure, admits specific cleavage by restriction enzymes over its entire genome. When used in a semi-in vitro replication complex, form I(d) gave significantly better template activity, and undergoes better primer extension in in vitro using Klenow. Thus form I(d) having a compact shape can behave as a better substrate in a few key enzymatic reactions.Item Blood and hepatic glutathione in linamarin fed rats.(1993-10-01) Uniyal, B P; Singh, L R; Mukherjee, S KFemale Sprague Dawley rats were fed 5 mg linamarin daily for 10 days. Reduced glutathione (GSH) levels in blood and liver of experimental rats were analysed. The results showed an increase of 45% and 33% glutathione levels in blood and liver respectively in experimental rats. This alteration in glutathione levels could be most likely either due to increased hepatic biosynthesis or as a consequence of decreased peripheral utilization which might be appreciated due to hypothyroidal status induced by linamarin feeding.Item Blood sugar lowering potentiality of selected Cucurbitaceae plants of Indian origin.(1989-08-01) Chandrasekar, B; Mukherjee, B; Mukherjee, S KUsing five experimental models, the blood sugar lowering efficacy of eight plants of Cucurbitaceae family has been assessed. The ethanolic extract of Cucumis sativus Linn, Cucumis melo utilissimum Roxb, Cucumis melo Linn, Benincasa hispida Thunb Cogn and Tricosanthes anguina Nees, when administered in 250 mg/kg dose, orally to rats failed to lower blood sugar or to depress the peak value, after glucose load. However, ethanolic extract of Momordica charantia Linn plant and Coccinia indica Whit and Arn root significantly lowered blood sugar in fasted model and depressed the peak value in glucose loaded model. Ethanolic extract of Tricosanthes dioica Roxb plant caused a significant lowering of blood sugar in fasted rats and depressed the peak value in glucose loaded single and longterm fed groups of rats. The ethanolic extract of the aerial part of T. dioica also induced significant depression in the peak values in the glucose loaded models.Item Carboxy terminal region of a chloroplast DNA polymerase accessory factor stimulates DNA polymerase activity.(2000-12-18) Gaikwad, A; Van Hop, D; Mukherjee, S Kp43, a glycoprotein of pea chloroplast (ct), acts as an accessory protein of pea chloroplast DNA polymerase. p43 binds to DNA, binds to ct-DNA polymerase and stimulates the ct-DNA polymerase activity. In the work presented here, the C-terminal domain of p43 (p22) has been overexpressed in E. coli. South Western analysis reveals that the recombinant p22 lacks in DNA binding activity. However, the recombinant p22 can form complex with the pea ct-DNA polymerase quite efficiently and stimulates the DNA polymerase activity to a greater extent than the native p43. Thus the DNA binding domain of p43 appears to be spatially separate from the domain responsible for the DNA polymerase accessory activity. The DNA binding domain is also highly O-glycosylated and loss of glycosylation of p43 leads to enhanced DNA binding as well as repression of ct-DNA polymerase activity. These findings allow us to propose a model to explain how glycosylation of p43 helps ct-DNA polymerase latch onto the DNA template for enhanced processivity. The predictive components of the model have been discussed.Item Cardiovascular manifestations of renal failure.(1967-07-01) Banerjea, J C; Mukherjee, S KItem Changes in pancreatic beta cell function during growth and reproductive maturity of rats.(1989-06-01) Mukherjee, B; Chandrasekar, B; Mukherjee, S KAn attempt has been made to study the changes, if any, in the efficiency of pancreatic beta cell function at different ages using one experimental model. For this, pancreatic islets were isolated from albino rats of 3, 8, 12 and 36 weeks of age and challenged with various concentrations of glucose (11.0, 16.7 and 22.2 mM). Significantly higher rate of glucose stimulated (pro)insulin biosynthesis was seen in the islets from 3 week old rats as compared to the islets obtained from 8, 12 and 36 week rats. On the other hand, immunoreactive insulin release was observed to be highest from islets of 8 week old rats followed by that of 12, 36 and 3 week old ones.Item Chrinic toxicity studies of Centchroman in rats & rhesus monkeys.(1977-12-01) Mukerjee, S S; Sethi, N; Srivastava, G N; Roy, A K; Nityanand, S; Mukherjee, S KItem Chronic toxicity studies of a hypoglycemic compound: centperalone in rats & rhesus monkeys.(1979-12-01) Mukerjee, S S; Sethi, N; Roy, A K; Srivastava, G N; Mukherjee, S KItem Chronic toxicity studies on 4-N-butylamino-1,2,3,4-tetrahydroacridine hydrochloride (Centbucridine)--a new local anaesthetic agent.(1982-04-01) Nityanand, S; Sethi, N; Srivastava, G N; Roy, A K; Mukherjee, S KItem Denatured supercoiled DNA--structural and biological activity.(1993-10-01) Santra, C R; Mukherjee, S K; Thakur, A RSupercoiled DNA on treatment with NaOH followed by neutralization produces a condensed structure (form Id). This structure does not split into topoisomers when run on long gel in presence of intercalating agents and the migration of this form does not change appreciably in presence or absence of ethidium bromide. Relaxation of form Id by topoisomerase I from pea chloroplast is facilitated more than form I. Single-stranded binding (SSB) protein binds more to form Id as evidenced from gel retardation study. Hydroxyl radical nicking is facilitated in this form. Compared to form I, this form produces half the number of transformants, but adsorption and penetration remain almost same in both the forms. Post-transformational growth using 32P labelled form I and form Id showed greater amount of degradation in form Id.Item Effect of argemone oil feeding on blood biochemistry and tissue changes in albino rats.(1972-05-01) Chandra, S; Mukherjee, S K; Sethi, NItem Effect of centpiperalone in insulin deficient diabetes.(1980-09-01) Chatterjee, A K; Murthi, P S; Mukherjee, S KItem Effect of centpiperalone, a new hypoglycemic agent on insulin biosynthesis & release from isolated pancreatic islets of rat.(1982-03-01) Chatterjee, A K; Mukherjee, B; Mukherjee, S K