Browsing by Author "Jain, Deepak"
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Item Association of Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus- An Analytical Cross-Sectional Study(Akshantala Enterprises Private Limited, 2020-04) Kaushal, Prateek; Purbey, Rahul; Jain, Deepak; Vashishta, Kshitiz D.; Gupta, Rajinder SinghNonalcoholic fatty liver disease (NAFLD) is a common liver disorder but is often ignored especially in diabetes mellitus and thus carries serious complications in the long run. We aim to study the association of NAFLD with type 2 diabetes mellitus.METHODSA prospective observational case control study of diabetic patients was done in a tertiary care teaching hospital. A total of 50 diabetic patients fulfilling the inclusion criteria were selected as cases while 50 age sex matched non-diabetic patients were included as controls. Complete clinical, laboratory and radiological data was collected from each patient and analyzed. Data was analyzed using statistical software SPSS ver. 21.RESULTSMean value of age in cases was 52.42 ± 10.24 years and in control was 54.04 ± 10.16 years (p>0.05). There were 56% males and 44% females in both the groups. Among the cases, majority (84%) of the patients were on Oral Hypoglycemic Agents (OHA). As compared to controls, cases had significantly higher SGOT and SGPT but significantly lower total bilirubin levels (p<0.05). In the lipid profile, cases had significantly higher TG, LDL and VLDL levels (p<0.05). Significant difference was seen in the USG findings between cases and controls. Majority (66%) of the patients in cases had abnormal USG findings showing liver thickness, as compared to 30% in controls.CONCLUSIONSType 2 diabetes was strongly found to be associated with development of NAFLD, and since most patients of NAFLD remain asymptomatic, all diabetic patients must be screened for development NAFLD.Item Comparative Analysis Of Various Electrophysiological Methods For The Diagnosis Of Carpal Tunnel Syndrome(World Wide Journals, 2019-07) Jain, Deepak; Saini, Pankaj KumarBACKGROUND:Patients with Mild Carpal tunnel syndrome (CTS) may not be picked up by routine nerve conduction methods. So, this study was performed to identify the most sensitive way to detect mild to moderate Carpal tunnel syndrome and to evaluate the sensitivity of different methods for diagnosis of carpal tunnel syndrome.MATERIALAND METHOD: We included sixty clinically confirmed CTS patients in our study. We recorded the clinical characteristics and laboratory features in a proforma. We also included sixty healthy age and sex-matched asymptomatic individuals as controls in our study. We excluded patients with underlying peripheral neuropathy. We included Median distal motor latency, Median distal sensory latency, Median-versus-ulnar 2nd Lumbrical-interossei comparison study, Median-versus-ulnar wrist-to-digit four comparison study, Median -versus- Radial thumb sensory study, Median-versus-ulnar motor distal latency difference, and Median-versus-ulnar sensory latency difference tests in our study.RESULTS:Out of sixty patients, female: male ratio was 2.3:1, and the mean age was 44.28±11.41 years. The mean symptom duration was 0.76±0.03 years. Out of 42 females, 38(90.4%) were engaged in daily household activities. In patients group median nerve distal motor latency was 5.024±2.05 ms, whereas sensory latency was 3.53±0.75 ms. We found maximum sensitivity in Median-versus-ulnar wrist-to-digit four comparison study (90.19%). In Median-versus-Radial thumb sensory study sensitivity was 88.23%, followed by Median-versus-ulnar 2nd Lumbrical- interossei comparison study (86.27%). We found lowest sensitivity (72.55%) in Median distal motor latency test.CONCLUSION:Electrophysiological tests including Median-versus-ulnar wrist-to-fourth digit comparison study, and comparative study of Median-versus-ulnar 2nd Lumbrical- interossei should be included to diagnose mild CTS patients with normal Median distal motor latency, and median distal sensory latency testsItem Dot-in-circle Sign of Mycetoma on Magnetic Resonance Imaging(International Research Organization for Life & Health Sciences (IROLHS), 2019-05) Jain, Deepak; S. B. S., Netam; Singh, Sanjay; Agrawal, SanjayMycetoma is a chronic granulomatous disease prevalent in tropical countries, but it also occurs in Europe and the United States.Early diagnosis is important as it has therapeutic implications. Although biopsy and microbiological culture provide the definitivediagnosis, these are difficult to achieve in many instances. The dot-in-circle sign is a recently proposed magnetic resonanceimaging (MRI) sign of mycetoma, which is likely to be highly specific. We present a case of mycetoma of the left calcaneumwith characteristic MRI features.Item Post cholecystectomy pseudotumor: beware of this masquerader.(2012-07) Arora, Ankur; Negi, Sanjay Singh; Thapar, Shalini; Mukund, Amar; Jain, Deepak; Bhatia, Vikram; Rastogi, ArchanaItem Radial nerve palsy with fracture shaft of the humerus treated with early limited nerve exploration and internal fixation.(2012-11) Jain, Deepak; Selhi, Harpal; Mahindra, Pankaj; Yamin, MohammadBackground and Objective: Radial nerve injuries associated with fractures of the humerus are the most common peripheral nerve injuries in long bone fractures. Management of these injuries remains controversial. Strong convictions for and against either line of treatment - conservative or operative can be drawn from the literature. This study evaluates the role of early limited exploration in these injuries. Methods: Sixteen patients with radial nerve palsy with fracture shaft of humerus treated with open reduction and internal fixation with plates were studied. Follow up of the patients was done with regard to intraoperative findings and pattern of recovery. Results: Radial nerve continuity with spontaneous clinical recovery was seen in all of our cases. The average time for onset of recovery in our study was two weeks for neurapraxia and 22 weeks for axonotmesis. The average time for complete recovery was five weeks for neurapraxia and 30 weeks for axonotmesis. 88% of our cases showed excellent and 12% showed good results. Conclusions and interpretation: Limited early nerve exploration of radial nerve is a reliable option while performing internal fixation for both primary as well as secondary radial nerve palsy with fracture of shaft of humerus.Item Role of Diffusion-weighted Imaging, Perfusion Magnetic Resonance Imaging, and Magnetic Resonance Spectroscopy in Evaluating Histopathologically Confirmed Brain Tumors in 3-Tesla Magnetic Resonance Imaging(International Research Organization for Life & Health Sciences (IROLHS), 2019-05) Jain, Deepak; Netam, Satya Bhuwan Singh; Patre, Vivek; Amle, Dnyanesh; Sahu, Rajiv; Gahine, RenukaObjective: Our aim was to evaluate the diagnostic capabilities of physiological magnetic resonance imaging (MRI) in differentiatingtype and grades of tumor and correlation with prospective histopathology results.Materials and Methods: We evaluated 70 patients in 3-tesla MRI preoperatively using conventional and physiological MRsequences (diffusion, perfusion, and spectroscopy) of common brain tumors who were prospectively confirmed by histopathology.Post-imaging analysis was done by available software and ratio was calculated. Data were expressed as mean ± standarddeviation and median (range) and Kolmogorov–Smirnov analysis was used to check distribution. Multiple statistical tests wereapplied and receiver operating characteristic (ROC) curve was plotted wherever feasible.Results: We obtained a significant difference in spectroscopic parameters, relative cerebral blood volume, and apparent diffusioncoefficient values between different tumor groups and also between different tumor grades. ROC curve plotted among groupsshowed sensitivity and specificity of diagnostic capability. Time-intensity curve showed a significant difference between differenttumor groups and correlation with grades of tumor.Conclusion: We propose an algorithm for differentiating different types and grades of common brain tumor using physiologicalMRI in addition to conventional MR sequences.Item Spectrum of Skin Manifestations in CKD: A Tertiary Care Center Experience from North India(IJCP Group, 2022-04) Aggarwal, HK; Jain, Deepak; Yadav, Lokender; Aggarwal, Arpit; Singh, JasminderIntroduction: Dermal manifestations in chronic kidney disease (CKD) patients may range from mild ones, like xerosis, skin pallor, pruritus, coated tongue, superficial infections and hair and nail changes, to severe life-threatening ones, like nephrogenic systemic fibrosis, which is a rare entity in current times. The present study was done to evaluate the spectrum of mucocutaneous manifestations in patients with CKD and to look for an association between them and various biochemical parameters and inflammatory markers. Material and methods: This study was a 1 year prospective, observational study conducted on adult patients with CKD who presented to the Nephrology clinic in Pt. BD Sharma PGIMS, Rohtak. Patients between the ages of 17 and 75 years with CKD stages II or more with dermatological conditions were included in this study. Each participant was subjected to detailed clinical, biochemical, radiological and dermatological examination by same consultants in order to avoid interpersonal variations. Various skin, mucosal, nail and hair manifestations along with cutaneous infections were analyzed across the spectrum of CKD. Results: Among cutaneous infections, fungal infections predominated, amongst which, onychomycosis was the most common. Xerosis was the most common dermatological disease and the prevalence of xerosis, skin pallor and pruritus was found to increase significantly from Stage II to Stage V and VD of CKD in a statistically significant manner. An association was found between xerosis and decreasing levels of hemoglobin and while ferritin was not different between patients with and without xerosis, high-sensitivity C-reactive protein (hs-CRP) was significantly higher in patients with xerosis. Similarly, hs-CRP levels were significantly elevated in patients with xerostomia and nail pallor as compared with those who did not have these conditions. Lastly, patients with nail pallor had significantly lower albumin. Conclusion: It was observed in our study that in CKD patients on hemodialysis and on conservative management, xerosis, pruritus, pigmentation, nail changes, oral mucosa changes and cutaneous infections were the predominant cutaneous manifestations. In patients with CKD, mucocutaneous manifestations progressively worsened as renal function deteriorated.Item Venous Thrombosis Complicating Acute Pancreatitis.(2016-04) Aggarwal, H.K.; Jain, Deepak; Rao, AvinashMost cases of pancreatitis are mild and self limited. On the other hand, approximately one quarter of patients with pancreatitis may develop vascular complications. Pancreatitis in combination with vascular complications is dangerous and potentially lethal. The survival of patients with pancreatitis and vascular complications depends on the early diagnosis of these complications. We report a case of an elderly male patient who had recurrent pancreatitis. On radiological imaging, patient was found have portal vein, splenic vein and superior mesenteric vein thrombosis. Patient recovered after emergent and timely management. The article focuses on the aspects of etiology, pathogenesis, diagnosis and management of acute pancreatitis with venous thrombosis.