Browsing by Author "Devi, C S"
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Item Alpha-tocopherol reduces doxorubicin-induced toxicity in rats--histological and biochemical evidences.(1990-04-01) Geetha, A; Sankar, R; Marar, T; Devi, C SThe beneficial effect of alpha-tocopherol on doxorubicin-induced toxicity was studied in rats. alpha-Tocopherol (400 mg/kg/day) was administered orally, daily for a period of 2 months along with/without doxorubicin (2.5 mg/kg, i v weekly once for 8 weeks). Histology showed liver necrosis, heart myocyte degeneration, glomerular and tubular degeneration, cellular infiltration and desquammation of intestinal mucosa in doxorubicin treated animals. There was a significant increase in lipid peroxide levels measured in terms of "TBA reactants" in all these organs. These changes were associated with elevated levels of serum enzymes such as transaminases, creatine kinase and lactate dehydrogenase. The pathological observations, were minimal in animals receiving both doxorubicin and alpha-tocopherol. The lipid peroxide levels were low with concomitant normal levels of serum and intestinal enzymes in those animals.Item Amyloidosis--a prospective study.(1971-05-16) Reddy, C R; Sulochana, G; Devi, C SItem Basal and post histamine acid outputs in control subjects and patients with duodenal ulcer.(1969-12-01) Devi, C S; Chari, A K; Devasankaraiah, G; Rao, G; Naidu, SItem Biochemical studies on the effect of S-1,3-butanediol of diabetes induced rats.(1995-04-01) Meenakshi, C; Kumari, K L; Devi, C SThe biochemical effect of S-1,3-butanediol on streptozotocin induced diabetic rats was studied. Rats were made diabetic by the intraperitoneal injection of 40 mg/kg body weight streptozotocin in sodium citrate buffer. A dosage of 25 mmol/kg body weight of S-1,3-butanediol was injected intraperitoneally for treatment. The streptozotocin induced diabetic rats showed a marked increase in blood glucose level, and significant increase in the level of cholesterol, triglycerides and free fatty acids. The glycogen levels in liver and kidney were greatly decreased in diabetic rats. Treatment with butanediol normalised the glucose and glycogen level but had no significant effect on protein and lipid levels.Item A case of sickle-cell thalassemia.(1969-06-01) Devi, C S; Rao, A N; Laxmidevi, S; Ramaiah, T Y; Reddy, C RItem Chemical analysis of hydatid cyst fluid in relation to the presence or absence of live scolices.(1971-07-01) Devi, C S; Tarachand, P; Devi, S L; Kumari, G S; Reddy, C RItem A comparative study of sodium, potassium and bilirubin in maternal and cord blood.(1967-09-01) Devi, C S; Naganna, BItem Congo red test in amyloidosis.(1970-08-01) Devi, C S; Sulochana, G; Reddy, C RItem Development of enzyme activity in the guinea-worm larvae.(1969-11-01) Devi, C S; Murthy, D P; Reddy, C RItem Effect of abana an ayurvedic formulation, on lipid peroxidation in experimental myocardial infarction in rats.(2000-08-01) Sasikumar, C S; Devi, C SThe present study was conducted to elucidate the antioxidant role of an ayurvedic formulation Abana in isoproterenol induced myocardial infarction in rats. In myocardial necrosis induced by isoproterenol, a significant increase in serum iron content with a significant decrease in plasma iron binding capacity, ceruloplasmin activity and glutathione level were observed. There was also a significant increase in lipid peroxides levels on isoproterenol administration. Activities of antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase, glutathione-s-transferase, glutathione reductase were decreased significantly in heart with isoproterenol-induced myocardial necrosis. Abana, produced a marked reversal of these metabolic changes related to myocardial infarction induced by isoproterenol. In conclusion ayurvedic formulation Abana exerts its effect by modulating lipid peroxidation and enhancing antioxidant and detoxifying enzyme systems.Item Effect of alpha-tocopherol on doxorubicin-induced changes in rat liver and heart microsomes.(1991-08-01) Geetha, A; Marar, T; Devi, C SRats were treated with doxorubicin (2.5 mg/kg body wt, iv) once a week for 8 weeks. Alpha-Tocopherol (400 mg/kg body wt/day) was co-administered orally for 2 months. Cytochrome-P450 (Cyt-P450) and Cytochrome-b5 (Cyt-b5) levels decreased significantly in doxorubicin treated rats. Significant decreases were observed in glucose-6-phosphatase, Cyt-P450 and Cyt-b5 reductase activities. In vitro lipid peroxidation study showed that alpha-tocopherol significantly minimises the lipid peroxide formation by doxorubicin. There was a significant change in microsomal cholesterol and phospholipid levels. Alpha-Tocopherol co-administration reduced the alterations in xenobiotic metabolising system and microsomal lipid levels. The results were discussed with reference to drug metabolising enzymes, lipid peroxidation and antioxidant nature of alpha-tocopherol.Item Effect of alpha-tocopherol on lipid peroxidation in isoproterenol induced myocardial infarction in rats.(1997-10-11) Ithayarasi, A P; Devi, C SThe effect of alpha-tocopherol pretreatment on lipid peroxidation and antioxidant status in isoproterenol induced myocardial infarction was studied in rats. Isoproterenol administered rats showed a significant increase in lipid peroxides in serum, heart and aorta. A significant increase in serum iron level with a significant decrease in iron binding capacity was also observed. The levels of antioxidants such as ceruloplasmin, glutathione and the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase decreased significantly in isoproterenol administered rats when compared to control. The activity of Na+K+ATPase decreased significantly and the activity of Ca2+ATPase increased significantly in heart and aorta of isoproterenol administered rats. alpha-tocopherol pretreated rats maintained the levels of antioxidants, membrane bound enzymes and activities of antioxidant enzymes near normal, on isoproterenol administration, thus establishing its effect as an antioxidant.Item Effect of alpha-tocopherol on peroxidative membrane damage caused by doxorubicin: an in vitro study in human erythrocytes.(1989-03-01) Geetha, A; Sankar, R; Devi, C SLevel of lipid peroxidation in doxorubicin treated human erythrocytes was studied and compared with that of cells pretreated with alpha-tocopherol. Erythrocytes treated with alpha-tocopherol had reduced level of lipid peroxidation with concomitantly lowered membrane damage. The membrane damage was monitored by the levels of conjugated diene absorption, lipid hydroperoxides and lipid peroxides. alpha-tocopherol was not effective in inhibiting the conjugated diene formation, but the lipid hydroperoxides and the lipid peroxide levels were significantly decreased. Methemoglobin level was found to be increased in alpha-tocopherol pretreated cells, which protects the membrane from damage. Erythrocyte membrane lipids were found to be decreased during doxorubicin treatment and alpha-tocopherol significantly reduced the membrane lipid breakdown. Level of reduced glutathione was maintained in alpha-tocopherol pretreated cells. These results are discussed with reference to the antioxidant property of alpha-tocopherol.Item Effect of aspirin on isoproterenol induced changes in lipid metabolism in rats.(1993-02-01) Manjula, T S; Devi, C SThe effect of aspirin on isoproterenol induced changes in lipid metabolism in rats was studied. Aspirin (1.2 mg/100 g/day) was administered orally for a period of 60 days along with/without isoproterenol (20 mg/100g sc twice at a time interval of 24 h for 2 days). Isoproterenol treated rats showed an increase in the levels of heart cholesterol, triglycerides and free fatty acids. The activity of cholesterol ester synthetase CES was increased significantly with concomitant increase in heart lipid peroxide levels in isoproterenol treatment. Aspirin treatment could restore the enzyme activity to near normal and also reduce the level of lipid peroxides. The lipid changes were minimum in rats treated with aspirin and isoproterenol.Item Effect of aspirin on isoproterenol induced myocardial infarction--a pilot study.(1992-08-01) Manjula, T S; Geetha, A; Devi, C SEffect of aspirin (1.2 mg/100 g body wt orally for 30 days) on myocardial infarction induced by isoproterenol (200 mg/kg body wt, subcutaneously for 2 days) has been studied in rats using activities of creatine kinase, aspartate amino transaminase, alanine amino transaminase and lactate dehydrogenase and levels of lipid peroxides as standard markers. Aspirin treatment is found to counteract the effect of isoproterenol on lipid peroxide formation and associated enzyme changes in serum and heart.Item Effect of aspirin on serum lipoprotein profile in rats subjected to myocardial stress by isoproterenol.(1992-06-01) Manjula, T S; Prema, A; Devi, C SThe effect of isoproterenol on the levels of serum lipoprotein profile were studied in rats. Rats were treated with isoproterenol (200 mg/100 g body weight, sc twice at an interval of 24 hr) for 2 days. Aspirin was administered orally 1.2 mg/100 g body weight, daily for 60 days. Isoproterenol treated rats showed decrease in the activities of hepatic and extrahepatic lipoprotein lipase. HDL cholesterol level was found to be decreased, significantly with increase in LDL cholesterol in isoproterenol treated rats. Aspirin treated rats showed marked reversal of these metabolic changes. The lipoprotein changes were minimum in rats treated with both aspirin and isoproterenol.Item Effect of doxorubicin on heart mitochondrial enzymes in rats: a protective role for alpha-tocopherol.(1992-07-01) Geetha, A; Devi, C SEffect of doxorubicin on heart mitochondrial enzymes was studied in rats with or without the administration of alpha-tocopherol. Rats were treated with doxorubicin 2.5 mg/kg, ip body wt once a week for 8 weeks. Alpha-tocopherol was co-administered orally for 2 months (400 mg/kg body wt daily). TCA cycle enzyme, NADH-dehydrogenase, cytochrome-C-oxidase and Na+,K(+)-ATPase activities were found to be decreased in doxorubicin treatment. A significant decrease in protease activity was observed with a concomitant increase in mitochondrial protein level. Mitochondrial lipid peroxide level was found to be increased with a decrease in thiol content. Alpha-tocopherol co-administration was found to maintain the mitochondrial enzyme activities as well as the thiol content. The results are discussed with reference to the antioxidant nature of alpha-tocopherol.Item Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats.(2001-07-08) Mahendran, P; Devi, C SDexamethasone (10 mg/kg body weight/day, s.c.) administered rats were treated with or without Garcinia cambogia fruit extract (1 g/kg body weight/day, orally) for 8 days. The administration of dexamethasone resulted in marked increase in the levels of triglycerides and cholesterol and free acids in both plasma and liver. The level of phospholipids increased in the plasma but decreased significantly in liver tissue after dexamethasone administration as compared to those in normal rats. The activities of lecithin cholesterol acyl transferase and hepatic lipoprotein lipase were lowered significantly after dexamethasone per se administration. The levels of HDL-triglycerides and HDL-cholesterol remained unchanged, while the LDL and VLDL increased significantly in dexamethasone administered rats. The lipid levels were maintained at near normalcy when co-treated with Garcinia cambogia extract in dexamethasone administered rats. This study reveals the undesirable changes in lipid profile on dexamethasone administration and the hypolipidemic property of Garcinia cambogia extract.Item Granulocytic sarcoma of the oral cavity.(2011-07) Seema, S; Jay, G R; Devi, C S; Aadithya, B U; Niharika, SItem Infectious hepatitis in pregnancy and puerperium--a study of 60 cases.(1969-09-01) Rao, A V; Devi, C S; Savithri, P; Seshirekha, E