Browsing by Author "Das, S"
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Item The 2009 Nobel Prize in chemistry: For studies of the structure and function of the ribosome.(2010-05) Kumar, V; Badve, A; Das, S; Ghosh, S; Bandopadhyay, RThe whole scientific community around the world waits for the day when years of hard work and brain storming research are honoured with the highest prize founded in the name of Sir Alfred Nobel. This year’s Nobel Prize in Chemistry (2009) was shared by three scientists Venkataraman Ramakrishnan, Thomas A. Steitz and Ada E. Yonath. They have shown what the ribosome looks like and how it functions at the atomic level. The Swedish Academy of Sciences agreed to bestow this honour of their research work on understanding the central dogma of protein synthesis. Using X-ray crystallography they established the 3D structure of protein synthesis machinery i.e. Ribosome. The ribosome reads the information from the mRNA and translates it into long chains of amino acids (polypeptide) and these molecules form proteins of various complex functions depending on its post-translational modifications. The trilogy of Nobel prizes regarding the central dogma, started with James Watson, Francis Crick and Maurice Wilkins elucidating, the atomic model of the double stranded DNA molecules in 1962. DNA is present in every cell of all organisms except for retro- viruses, even it is considered as the blueprint of life. As the activity of any process in cellular functions finally depends on proteins, in recent science, transcription and translation processes are considered more important than replication. Thus the work of Roger D. Kornberg on RNA synthesis in 2006 is also an important milestone. Remarkably X-ray crystallography played a significant role for all of the above three important research works.20 One of the recent issues in Current Science, explained briefly about all the Nobel Laureates in 2009.1 In this regard, we thought it would be a good idea to focus on Chemistry due to the involvement of an Indian-American Scientist Dr Ramakrishnan.Item Abnormal spicules on the inferior aspect of anterior arch of atlas vertebra.(2007-03-06) Das, S; Suri, R; Kapur, VAnterior arch of the atlas vertebra is known to exhibit various developmental anomalies. Bony outgrowths, osteophytes, clefts and aplasia of the anterior and posterior arches of the atlas have received special attention by research workers. To the best of our knowledge, not many osteological studies have defined the spicules on the anterior arch of the atlas. The present study describes an abnormal atlas vertebra with 2 spicules on the inferior aspect, 2 additional facets inferior to the superior articular facets and a peculiar facet to the left of the posterior tubercle. These abnormal spicules may cause dysphagia or involve atlanto-occipital movements. Such anomalies may be misinterpreted in routine X rays as a degenerative disease. However, asymptomatic cases remain undetected throughout life. Such anomalies may be important in radiological, clinical, forensic and anthropological studies.Item Acute myelofibrosis.(1997-10-28) Das, S; Prabhakar, B RAcute myelofibrosis is a rare disorder. Five such cases have been diagnosed out of 3,149 Bone Marrow (B.M) Aspirations and Trephine Biopsies studied over a period of eight and a half years. Four out of five patients were males and the other female. Their age ranged from 14-71 years. Neither splenomegaly not red cell poikilocytosis (tear drop cells) were prominant features. B.M. trephine biopsy showed increase of atypical megakaryocytes/megakaryoblasts and marked fibrosis. There was rapid downhill clinical course of the disease in all cases.Item Alopecia universalis in a case of systemic lupus erythematosus.(2002-08-08) Chaudhuri, S; Basu, K; Dhar, M C; Das, S; Chatterjee, G; Banerjee, G; Mitra, KWe report a case of systemic lupus erythematosus (SLE) who presented with alopecia universalis. MR, a 23 years female patient was admitted with alopecia universalis and other features of SLE like peripheral arthritis, fever, nephritis, butterfly rash over the malar regions, positive ANA and anti-ds DNA antibodies. There was a gap of four years between the onset of alopecia universalis and other clinical features of SLE. The alopecia was of non-scarry variety and responded to systemic and topical steroids.Item The analgesic and acute anti-inflammatory effect of the ethanolic extract of the leaves of Paederia foetida (EEPF) on experimental animal models.(2012-07) Das, S; Bordoloi, P k; Saikia, P; Kanodia, LObjective:To study the analgesic and acute anti-inflammatory effect of the ethanolic extract of the leaves of Paederia foetida (EEPF) on experimental animal models. Materials and Methods: Fresh leaves were collected, air-dried, powdered, and percolated in 95% ethanol. Acute toxicity test was done according to OECD guidelines. Healthy albino rats (150-200 gm) of either sex were taken and divided into five groups with six animals in each group for central analgesic activity by tail flick method. Peripheral analgesic activity by 1% glacial acetic acid induced writhing test by taking albino mice (20-30 gm) of either sex which were divided into three groups with six animals in each. EEPF was used in a dose of 500 mg/kg bodyweight subcutaneously for tail-flick method and orally for writhing test. In tail-flick method the basal reaction time was taken and a cut-off period of 10 sec was observed. Reaction time were recorded at predrug, 15, 30, 60, 90, 120, 150 and 180 minutes after administration of drug . The standard drug used for central analgesic activity was pethidine 5 mg/kg bw, naloxone 1mg/kg as antagonist and naloxone 1mg/kg bw with 500mg/kg bw of EEPF to study the central mechanism of action. The standard drug used for peripheral analgesic activity was aspirin 100mg/kg bw orally. A control group was maintained in all the models. For anti-inflammatory study, three groups of animals of either sex (n = 6), weighing 150-200g of the species Rattus norvegicus were taken for the study. Group A was taken as control (Normal salie, 10 mL/kg body weight), Group B as test group (EEPF 500 mg/kg body weight), and Group C as standard (Aspirin 100 mg/kg body weight). The animals were studied for acute inflammation by Carrageenan-induced rat paw edema. Statistical analysis was done by one-way analysis of variance followed by multiple comparison tests. Results: EEPF significantly increased the reaction time in tail-flick method (p<0.05) whereas the combination of naloxone and EEPF decreased the reaction time indicating that naloxone inhibits the analgesic effect of EEPF. In 1% glacial acetic acid induced writhing EEPF reduced writhing significantly In acute inflammation, there was significant inhibition of paw edema in Groups B, C in comparison with Group A (P < 0.05). Conclusion:The ethanolic extract of Paederia foetida has significant analgesic and anti-inflammatory activity.Item Anatomico-radiological study of asymmetrical articular facets on occipital condyles and its clinical implications.(2008-04-05) Das, S; Chaudhuri, J DThe articular facets on the inferior aspect of the occipital condyles, articulate with the superior articular facets of the first cervical (atlas) vertebra, to form the atlanto-occipital joint. The present case, reports the asymmetrical dimensions of the facets on the occipital condyles of a human dried skull. The anatomico-radiological study of asymmetrical articular facets on the occipital condyles, may be helpful for academicians, neuro-surgeons, clinicians and radiologists in day to day clinical practice.Item Anti-amoebic antibody levels in gastro-intestinal disorders.(1992-03-01) Basu, A; Das, S; Sanyal, S; Bhattacharjee, A; Ghose, E; Sahadalal, B; Sanyal, SSerum anti-amoebic antibody levels were studied in 91 cases having clinical presentation of bowel disorders and 31 cases of control. Anti-amoebic antibody was positive in significant dilutions in 38 cases (31.15%) in total comprising 9 cases out of 22 cases showing presence of Ent histolytica cyst in stool, 13 cases who were positive for ova, parasite and cysts other than Ent histolytica in stool and 16 cases out of 70 cases with negative stool findings. It was positive in 5 cases out of 9 diagnosed cases of amoebic liver abscess. Assessment of immunoglobulin levels in amoebic liver abscess cases revealed high levels of immunoglobulin G and immunoglobulin M.Item Antibacterial activity of local anaesthetics procaine & lignocaine.(1988-05-01) Dastidar, S G; Das, S; Mookerjee, M; Chattopadhyay, D; Ray, S; Chakrabarty, A NItem Antigenic patterns of pre & post menopausal normal cervix.(1980-12-01) Das, S; Bose, S R; Chowdhury, J RItem Antihypertensive and haemodynamic effects of clonidine-hydrochlorothiazide combination.(1977-05-01) Basu, J; Chakrabarty, K; Majumder, G; Neelakantan, C; Maity, A K; Bardhan, A K; Das, S; Ghosh, J C; Chhetri, M KItem Antimicrobial susceptibility profile of Neisseria gonorrhoeae at STI clinic.(2008-01-30) Shilpee, C; Ramachandran, V G; Das, S; Bhattacharya, S NA total of 100 consecutive patients who attended a sexually transmitted infections clinic were studied. Thirteen had gonococcal urethritis, of which 10 showed growth of Neisseria gonorrhoeae on culture. All the isolates were tested for antimicrobial susceptibility by Australian Gonococcal Surveillance Programme (AGSP) method and beta lactamase production by chromogenic cephalosporin test. Four patients were co-infected with each of the following: HIV, HBV and Chlamydia trachomatis . Gonococcal urethritis (13%) was found more in male patients. Ten percent gonococcal isolates were penicillinase-producing N. gonorrhoeae , and another 10% were tetracycline-resistant N. gonorrhoeae .Item An approach for identification of individuals in a mass disaster in Indian set up.(2011-04) Das, S; Pandey, S K; Chakraborty, PIn the changing scenario of mass disaster, which has become almost one of the stories of daily news paper, Disaster Victim Identification has become important for its medico-legal as well as nations socio-economical aspects. This expertise gives the Forensic Experts a resource advice in dealing with human identification in a simpler way in Indian context. The idea of this work was born after the Ganeswari express accident that occurred in West Bengal, in May 2010, after which the situation demeaned a discussion between the Forensic Experts, Forensic Scientists and police personnel to frame a simpler guideline for Disaster Victim Identification. The recommendations made in this paper, as well as in many cited references, are intended to provide the forensic experts the minimum guidance for victim identification by photography and storing samples suitable for DNA analysis. It also gives a guideline for matching the DNA samples with the relative of the victims that will provide better chances of victim identification.Item Attitude and practice of self-medication among 2nd-year dental students in a tertiary care teaching hospital: A questionnaire-based cross-sectional study(Mrs Dipika Charan of MedScience (India) Publications, 2022-09) Das, S; Parida, S; Misra, D; Bose, M.Background: It is a common believe that self medication prevails more in medical students. Dental students do believe in self medication. With this background, current study aimed to determine the attitude and practice of self medication among dental students. Aim and Objective: To know prevalence, attitude and practice of self medication among dental students in a dental college. Materials and Methods: A descriptive cross-sectional study was conducted among 2nd year dental students in a tertiary care teaching hospital to assess attitude and practice regarding self-medication. Data were collected from 90 students using a semi-structured self-administered questionnaire. Results: The study finding revealed that overall prevalence of self medication is 86.67% among the participants. There is an increase in prevalence of self medication from 58.97 to 86.67% after joining to professional course. Most common source of self medication is senior抯 advice (92.30%) followed by book reference (83.33%). Most common disease for which self medication is used are fever, headache/body ache, cold/flu (100%) followed by acid peptic disease (92.30%). The use of self medication is more in communicable/infectious disease (91.02%) than noncommunicable disease (62.82%). Most commonly used drug for self medication are analgesics, antiallergics and antipyretics (100%) followed by antacid/PPI (84.61%). The prevalence of use of antibiotics among the participants are 73.07%. 26.29% participants use herbal medication as self medication. Most of the participants use self medication as and when basis (52.57%). Only 25.64% participant took full course of the medication and 21.79% participants use self medication for long term. Most of the participants strongly agree or agree for self medication in community and among dental students. About 54% disagree saying medicine should be prescribed by licensed medical practitioner. Conclusion: Attitude and practice of the students towards self-medication was positive and reason being dental students and influence of seniors. Since they are in the initial year of course with inadequate knowledge, awareness must be created about appropriate use and adverse drug reaction arising from self-medication.Item Autoimmune diseases and diabetes.(1977-04-16) Chhetri, M K; Das, SItem Bilateral testicular tumours.(1968-06-01) Das, SItem Biochemical effect of non-antiovulatory doses of different progestins on cycling rat uterus.(1980-04-01) Guin, A K; Das, S; Datta, S C; Dey, S; Sengupta, DItem Biofilm formation by Candida species on intrauretheral catheter and its antifungal susceptibility profile.(2014-10) Chaudhary, S; Gupta, C; Das, S; Saha, R; Rani, M; Ramachandran, V GItem Bone marrow morphology in multiple myeloma.(1995-09-01) Kuriakose, P; Das, S; Mani, AThis study was undertaken at the Christian Medical College and Hospital, Ludhiana, encompassing all patients of multiple myeloma presenting between January 01, 1982 and December 31, 1991. In all, 89 patients were included. The may Grunwald Giemsa stained bone marrow aspiration slides of each patient was examined under oil- immersion and a morphological grading made as mature (12 patients), immature (53) and plasmablastic (24). The estimated median survival for the mature category was 55 months, for immature 23 months and for plasmablastic two months. The estimated median survival on combining the mature of immature groups was 52 months, and on comparing this with the plasmablastic group, the difference in survival was found to be statistically significant (p < 0.05).Item Burden of bacterial contamination: A cross-sectional study to estimate the bacterial isolates from the surfaces of a bacteriology laboratory(Mrs Dipika Charan of MedScience (India) Publications, 2022-04) Ghosh, R; Das, S; Konar, J.Background: Contamination in a bacteriology laboratory setup may result in erroneous interpretation. Aim and Objective: To estimate the bacterial isolates from different surfaces of the bacteriology laboratory of a tertiary care hospital. Materials and Methods: A total number of 165 samples were taken from different surfaces of the laboratory including tabletops, floor, walls, and workbench tops at the beginning of morning session for consecutive thirty working days (June 2019). Surface swab technique was followed using pre-incubated Nutrient agar (Basal plate), Mac-conkey’s agar (Selective and differential media), and Blood agar plates (enriched media). Aerobic incubation was done overnight at 37°C. Discrete colonies were studied by Gram, Ziehl-Neelsen, and Albert staining followed by the tests for motility and a series of biochemical reactions. Results: Out of 165 collected swabs, growth was observed in 23 (13.93%). Out of these 23 isolates, none was from the workbench top. Majority (47.82% i.e., 11/23) was from the floor. Amongst 23 isolates, 14 (60.86%) were Gram-positive in nature and 7 (30.43%) found to be motile. Isolated bacteria comprised Micrococcus spp. (34.78% i.e., 8/23), Pseudomonas spp. (17.39%,4/23), Coagulase-negative Staphylococcus spp. (13.04% i.e., 3/23), Bacillus spp. (13.04%, i.e., 3/23) and Acinetobacter spp. (21.73% i.e., 5/23). From floor, majority of the isolates were Micrococcus spp. (45.45%, i.e., 5/11) whereas in wall, mostly Bacillus spp. (33.33%, i.e., 3/9) and tabletop, all of the isolates were Coagulase-negative Staphylococcus spp. Conclusion: Vigilant disinfection and maintenance of personal hygiene of laboratory workers are essential to eliminate contamination.Item C-peptide response to glycaemic stimuli.(1987-05-01) Samal, K C; Das, S; Parija, C R; Tripathy, B B